解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Patients with classic hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) typically have high levels of Epstein-Barr virus (EBV) DNA in T cells and/or natural killer (NK) cells in blood and skin lesions induced by sun exposure that are infiltrated with EBV-infected lymphocytes. HVLPD is very rare in the Unit...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood.2018893750
更新日期:2019-06-27 00:00:00
abstract::Targeted sequencing of 103 leukemia-associated genes in leukemia cells from 841 treatment-naive patients with chronic lymphocytic leukemia (CLL) identified 89 (11%) patients as having CLL cells with mutations in genes encoding proteins that putatively are involved in hedgehog (Hh) signaling. Consistent with this findi...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-09-873695
更新日期:2019-06-20 00:00:00
abstract::This study was performed to assess the utility of tumor-derived fragmentary DNA, or circulating tumor DNA (ctDNA), for identifying high-risk patients for relapse of acute myeloid leukemia and myelodysplastic syndrome (AML/MDS) after undergoing myeloablative allogeneic hematopoietic stem cell transplantation (alloSCT)....
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-10-880690
更新日期:2019-06-20 00:00:00
abstract::Current guidelines advocate to limit red blood cell (RBC) transfusion during surgery, but the feasibility and safety of such a strategy remain unclear, as the majority of evidence is based on postoperatively stable patients. We assessed the effects of a protocol aiming to restrict RBC transfusion throughout hospitaliz...
journal_title:Blood
pub_type: 杂志文章,随机对照试验
doi:10.1182/blood-2018-10-877530
更新日期:2019-06-20 00:00:00
abstract::Inactivation of the tumor suppressor p53 is essential for unrestrained growth of cancers. However, only 11% of hematological malignancies have mutant p53. Mechanisms that cause wild-type p53 dysfunction and promote leukemia are inadequately deciphered. The stem cell protein Asrij/OCIAD1 is misexpressed in several huma...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood.2019000530
更新日期:2019-05-30 00:00:00
abstract::The microbiota has emerged as an important regulator of the host immunity by the induction, functional modulation, or suppression of local and systemic immune responses. In return, the host immune system restricts translocation and fine tunes the composition and distribution of the microbiota to maintain a beneficial ...
journal_title:Blood
pub_type: 杂志文章,评审
doi:10.1182/blood-2018-11-844555
更新日期:2019-05-16 00:00:00
abstract::Ras-related C3 botulinum toxin substrate 2 (RAC2), through interactions with reduced NAD phosphate oxidase component p67 phox , activates neutrophil superoxide production, whereas interactions with p21-activated kinase are necessary for fMLF-induced actin remodeling. We id...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-11-886028
更新日期:2019-05-02 00:00:00
abstract::Human ADAMTS13 is a multidomain protein with metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C), and spacer (S) domains, followed by 7 additional T domains and 2 CUB (complement components C1r and C1s, sea urchin protein Uegf, and bone morphogenetic protein-1) domains. ADAMTS13 inhibits the ...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-11-886309
更新日期:2019-04-25 00:00:00
abstract::Primary effusion lymphoma (PEL) is an aggressive HIV-associated lymphoma with a relatively poor prognosis in the era of effective HIV therapy. Kaposi sarcoma herpesvirus (KSHV) is the etiologic agent, and ∼80% of tumors are coinfected with Epstein-Barr virus (EBV). A better understanding of how KSHV-related immune dys...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2019-01-893339
更新日期:2019-04-18 00:00:00
abstract::This phase 1/2 study assessed parsaclisib (INCB050465), a next-generation, potent, and highly selective phosphatidylinositol 3-kinase δ (PI3Kδ) inhibitor, in patients with relapsed or refractory B-cell malignancies, alone or in combination with a Janus kinase 1 inhibitor (itacitinib) or chemotherapy (rituximab, ifosfa...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-08-867499
更新日期:2019-04-18 00:00:00
abstract::Autologous T cells engineered to express a CD19-specific chimeric antigen receptor (CAR) have produced impressive minimal residual disease-negative (MRD-negative) complete remission (CR) rates in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). However, the factors associated with durable...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-11-883710
更新日期:2019-04-11 00:00:00
abstract::Myelofibrosis in myeloproliferative neoplasms (MPNs) with mutations such as JAK2V617F is an unfavorable sign for uncontrollable disease progression in the clinic and is complicated with osteosclerosis whose pathogenesis is largely unknown. Because several studies have revealed that macrophages are an indispensable sup...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-09-876615
更新日期:2019-04-11 00:00:00
abstract::Hematopoietic stem cell (HSC) homeostasis is controlled by cytokine receptor-mediated Janus kinase 2 (JAK2) signaling. We previously found that JAK2 is promptly ubiquitinated upon cytokine stimulation. Whether a competing JAK2 deubiquitination activity exists is unknown. LNK is an essential adaptor protein that constr...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-10-877563
更新日期:2019-04-04 00:00:00
abstract::D assemblies make up half of the von Willebrand factor (VWF), yet are of unknown structure. D1 and D2 in the prodomain and D'D3 in mature VWF at Golgi pH form helical VWF tubules in Weibel Palade bodies and template dimerization of D3 through disulfides to form ultralong VWF concatemers. D'D3 forms the binding site fo...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-10-876300
更新日期:2019-04-04 00:00:00
abstract::Persistent NF-κB activation is a hallmark of the malignant Hodgkin/Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL). Genomic lesions, Epstein-Barr virus infection, soluble factors, and tumor-microenvironment interactions contribute to this activation. Here, in an unbiased approach to identify the cHL cel...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-08-871293
更新日期:2019-03-28 00:00:00
abstract::The erythroblastic island (EI), formed by a central macrophage and developing erythroblasts (EBs), was first described decades ago and was recently shown to play an in vivo role in homeostatic and pathological erythropoiesis. The exact molecular mechanisms, however, mediating the interactions between macrophages and E...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-11-888180
更新日期:2019-03-14 00:00:00
abstract::Best known for presenting antigenic peptides to CD4+ T cells, major histocompatibility complex class II (MHC II) also transmits or may modify intracellular signals. Here, we show that MHC II cell-autonomously regulates the balance between self-renewal and differentiation in B-cell precursors, as well as in malignant B...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-11-885467
更新日期:2019-03-07 00:00:00
abstract::NOTCH1 is mutated in 10% of chronic lymphocytic leukemia (CLL) patients and is associated with poor outcome. However, NOTCH1 activation is identified in approximately one-half of CLL cases even in the absence of NOTCH1 mutations. Hence, there appear to be additional factors responsible for the impairment of NOTCH1 deg...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-09-874529
更新日期:2019-02-21 00:00:00
abstract::The canonical role of the hemostatic and fibrinolytic systems is to maintain vascular integrity. Perturbations in either system can prompt primary pathological end points of hemorrhage or thrombosis with vessel occlusion. However, fibrin(ogen) and proteases controlling its deposition and clearance, including (pro)thro...
journal_title:Blood
pub_type: 杂志文章,评审
doi:10.1182/blood-2018-07-818211
更新日期:2019-02-07 00:00:00
abstract::Ravulizumab (ALXN1210), a new complement C5 inhibitor, provides immediate, complete, and sustained C5 inhibition. This phase 3, open-label study assessed the noninferiority of ravulizumab to eculizumab in complement inhibitor-naive adults with paroxysmal nocturnal hemoglobinuria (PNH). Patients with lactate dehydrogen...
journal_title:Blood
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1182/blood-2018-09-876136
更新日期:2019-02-07 00:00:00
abstract::In contrast to other diverse therapies for the X-linked bleeding disorder hemophilia that are currently in clinical development, gene therapy holds the promise of a lasting cure with a single drug administration. Near-to-complete correction of hemophilia A (factor VIII deficiency) and hemophilia B (factor IX deficienc...
journal_title:Blood
pub_type: 杂志文章,评审
doi:10.1182/blood-2018-07-820720
更新日期:2019-01-31 00:00:00
abstract::Dendritic cells (DCs) are a key cell type in the initiation of the adaptive immune response. Recently, an additional role for DCs in suppressing myeloproliferation was discovered. Myeloproliferative disorder (MPD) was observed in murine studies with constitutive depletion of DCs, as well as in patients with congenital...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-05-850321
更新日期:2019-01-24 00:00:00
abstract::Leukemia in infants is rare but generates tremendous interest due to its aggressive clinical presentation in a uniquely vulnerable host, its poor response to current therapies, and its fascinating biology. Increasingly, these biological insights are pointing the way toward novel therapeutic approaches. Using represent...
journal_title:Blood
pub_type: 杂志文章,随机对照试验
doi:10.1182/blood-2018-04-785980
更新日期:2019-01-17 00:00:00
abstract::Graft-versus-host disease (GVHD) remains one of the major complications after allogeneic bone marrow transplantation (allo-BMT). Sirtuin-1 (Sirt-1) plays a crucial role in various biological processes including cellular senescence, metabolism, and inflammatory responses. Sirt-1 deacetylation regulates different transc...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-07-863233
更新日期:2019-01-17 00:00:00
abstract::The introduction of agents targeted at specific molecular events is changing the treatment paradigms in a number of malignancies. Historically, we have relied entirely on DNA-interactive, cytotoxic drugs for treating patients with leukemia. Increased understanding of the leukemic cell biology and pathogenesis, and the...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-08-832105
更新日期:2019-01-10 00:00:00
abstract::Inhibition of the B-cell receptor (BCR) signaling pathway is a promising treatment strategy in multiple B-cell malignancies. However, the role of BCR blockade in diffuse large B-cell lymphoma (DLBCL) remains undefined. We recently characterized primary DLBCL subsets with distinct genetic bases for perturbed BCR/phosph...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-08-872465
更新日期:2019-01-03 00:00:00
abstract::Myeloproliferative neoplasms (MPNs) are a group of blood cancers that arise following the sequential acquisition of genetic lesions in hematopoietic stem and progenitor cells (HSPCs). We identify mutational cooperation between Jak2V617F expression and Dnmt3a loss that drives progression from early-stage polycythemia v...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-04-846220
更新日期:2018-12-27 00:00:00
abstract::Azacitidine treatment of myelodysplastic syndromes (MDSs) generally exacerbates thrombocytopenia during the first treatment cycles. A Study of Eltrombopag in Myelodysplastic Syndromes Receiving Azacitidine (SUPPORT), a phase 3, randomized, double-blind, placebo-controlled study, investigated the platelet supportive ef...
journal_title:Blood
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1182/blood-2018-06-855221
更新日期:2018-12-20 00:00:00
abstract::Antithrombotic therapies reduce cardiovascular diseases by preventing arterial thrombosis and thromboembolism, but at expense of increased bleeding risks. Arterial thrombosis studies using genetically modified mice have been invaluable for identification of new molecular targets. Because of low sample sizes and hetero...
journal_title:Blood
pub_type: 杂志文章,评审
doi:10.1182/blood-2018-02-831982
更新日期:2018-12-13 00:00:00
abstract::Andexanet alfa, a reversing agent for anticoagulants that inhibit factor Xa, has recently been licensed in the United States. We discuss the impact of this licensure on current practice and review in detail the problems of a neglected and growing clinical area: reversing the anticoagulation effect of factor Xa inhibit...
journal_title:Blood
pub_type: 杂志文章,评审
doi:10.1182/blood-2018-06-850396
更新日期:2018-12-06 00:00:00
abstract::The intestinal microbiota in allogeneic bone marrow transplant (allo-BMT) recipients modulates graft-versus-host disease (GVHD), a systemic inflammatory state initiated by donor T cells that leads to colitis, a key determinant of GVHD severity. Indole or indole derivatives produced by tryptophan metabolism in the inte...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-03-838193
更新日期:2018-12-06 00:00:00
abstract::Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) affect >200 000 individuals yearly with a 40% mortality rate. Although platelets are implicated in the progression of ALI/ARDS, their exact role remains undefined. Triggering receptor expressed in myeloid cells (TREM)-like transcript 1 (TLT-1) is f...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-03-841593
更新日期:2018-12-06 00:00:00
abstract::Autologous T cells targeting Epstein-Barr virus (EBV) latent membrane proteins (LMPs) have shown safety and efficacy in the treatment of patients with type 2 latency EBV-associated lymphomas for whom standard therapies have failed, including high-dose chemotherapy followed by autologous stem-cell rescue. However, the ...
journal_title:Blood
pub_type: 临床试验,杂志文章
doi:10.1182/blood-2018-07-863654
更新日期:2018-11-29 00:00:00
abstract::Sickle cell trait (SCT) is unique among the carrier states that are identified during newborn screening. Unlike other heterozygous states for rare recessive diseases, SCT is exceedingly prevalent throughout regions of the world, making sickle cell disease one of the most common monogenetic diseases worldwide. Because ...
journal_title:Blood
pub_type: 杂志文章,评审
doi:10.1182/blood-2018-06-848705
更新日期:2018-11-29 00:00:00
abstract::Ibrutinib is highly efficacious and used at 420 mg/d for treatment of chronic lymphocytic leukemia (CLL). We previously demonstrated a decline in Bruton's tyrosine kinase (BTK) protein levels in CLL cells after 1 cycle of ibrutinib, suggesting ibrutinib dose could be lowered after the first cycle without loss of biolo...
journal_title:Blood
pub_type: 临床试验,杂志文章
doi:10.1182/blood-2018-06-860593
更新日期:2018-11-22 00:00:00
abstract::Ferroportin (FPN), the only known vertebrate iron exporter, transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues and cells in vivo. Most of the circulating iron is consumed by erythroid cells to synthesize hemoglobin. Here we found that erythroid cells not only co...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-04-842997
更新日期:2018-11-08 00:00:00
abstract::Primary effusion lymphoma (PEL) is a rare B-cell malignancy that most often occurs in immunocompromised patients, such as HIV-infected individuals and patients receiving organ transplantation. The main characteristic of PEL is neoplastic effusions in body cavities without detectable tumor masses. The onset of the dise...
journal_title:Blood
pub_type: 杂志文章,评审
doi:10.1182/blood-2018-03-791426
更新日期:2018-11-01 00:00:00
abstract::The Hermes receptor CD44 is a multifunctional adhesion molecule that plays an essential role in the homing and invasion of neoplastic stem cells in various myeloid malignancies. Although mast cells (MCs) reportedly express CD44, little is known about the regulation and function of this receptor in neoplastic cells in ...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2018-02-833582
更新日期:2018-11-01 00:00:00
abstract::Adoptive transfer of patient-derived T cells modified to express chimeric antigen receptors (CARTs) has demonstrated dramatic success in relapsed/refractory pre-B-cell acute lymphoblastic leukemia (ALL), but response and durability of remission requires exponential CART expansion and persistence. Tumors are known to a...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2017-12-815548
更新日期:2018-11-01 00:00:00
abstract::The incidence of venous thromboembolism (VTE) in adult patients with sickle cell disease (SCD) is high. However, overlapping features between the clinical presentation of VTE and SCD complications and a low index of suspicion for thrombosis can influence patient management decisions. VTE in SCD can therefore present m...
journal_title:Blood
pub_type: 杂志文章,评审
doi:10.1182/blood-2018-03-822593
更新日期:2018-10-25 00:00:00